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It is used to make direct comparisons of nutrient profiles with differing moisture contents. Ask your veterinarian for alternatives. For help transitioning to a new pet food, visit HillsPet. Groundbreaking nutrition that can save the lives of sick pets and comfort the people who care for them.

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In conjugation, adjacent tyrosyl residues are paired together. The entire complex re-enters the follicular cell by endocytosis.

Proteolysis by various proteases liberates thyroxine and triiodothyronine molecules, which enters the blood. Hyperthyroidism is the clinical condition in which the thyroid gland produces excessive amounts of the thyroid hormones T3 and T4. Hyperthyroidism occurs in different species as the result of different mechanisms. Robert J. In dogs, hyperthyroidism is a relatively uncommon disease that is usually caused by a thyroid carcinoma i.

Figure 4. Hyperthyroid cat presented for radioiodine therapy. Note the severe weight loss and muscle wasting. In cats, hyperthyroidism is almost always caused by one or more small benign tumors of the thyroid gland called adenomas [5].

These thyroid adenomas function autonomously and hence produce excessive amounts of thyroid hormones. Henry S. Plummer in people that is also caused by autonomously functioning thyroid adenoma s [6]. Excessive thyroid hormone levels lead to an increased metabolic rate that if unchecked, ultimately proves life limiting. Feline hyperthyroidism is currently the most commonly diagnosed endocrine disease of the cat.

Since its initial discovery in , the diagnosis of hyperthyroidism in cats has continued to increase, reaching epidemic proportions. Our incomplete understanding of the cause or causes of hyperthyroidism in cats has precluded effective prevention efforts. Since its recognition in , a major suspect of the cause for the thyroid adenomas that lead to hyperthyroidism in cats has been commercially produced cat foods. Because the production of thyroid hormones requires the incorporation of iodine into the hormone precursor thyroglobulin, iodine deficiency will lead to the reduced production of thyroid hormones.

History of iodine deficiency in man. The concept that iodine deficiency leads to the reduced production of thyroid hormones is well established. Indeed the history of iodine deficiency dates back to the ancient Greeks that recognized the value in treating patients with goiters thyroid enlargements using marine sponges. The Greeks however did not know that the thyroid enlargement they witnessed was due to the hypertrophy of normal thyroid cells in response to chronic iodine deficiency.

Figure 5. Large goiter thyroid enlargement due to iodine deficiency. Iodine deficiency in patients with normal thyroid function results in the reduced production of thyroid hormones.

This initially subclinical hypothyroidism stimulates the hypothalamus in the brain to increase production of thyrotropin releasing hormone TRH which in turn stimulates the increased production and release of thyroid stimulating hormone TSH from the pituitary gland. The effect of increased TSH production by the pituitary is stimulation of the thyroid cells to grow and produce thyroid hormones. The chronic increase in TSH levels in the blood that accompanies iodine deficiency ultimately leads to the hypertrophy of the normal thyroid gland causing a goiter see figure above [9].

Iodine deficiency is an important human health problem throughout much of the world. The older an exposed soil surface, the more likely the iodine has been leached away by erosion. Mountainous regions, such as the Himalayas, the Andes, and the Alps, and flooded river valleys, such as the Ganges, are among the most severely iodine-deficient areas in the world.

People in these areas commonly have thyroid enlargement goiter , and often thyroid nodules as well. In the United States, dietary iodine deficiency was essentially eliminated early in the last century with the addition of iodine to salt and its presence in milk and bread products [8]. Potential role of iodine deficiency in the etiology of feline hyperthyroidism. Hyperthyroidism was first diagnosed in cats in , and its diagnosis has steadily increased ever since.

Effect of feeding an iodine restricted diet in cats with spontaneous hyperthyroidism. J Vet Intern Med ; — Titration of dietary iodine for maintaining normal serum thyroxine concentrations in hyperthyroid cats abstract J Vet Intern Med ; Titration of dietary iodine for reducing serum thyroxine concentrations in newly diagnosed hyperthyroid cats abstract.

J Vet Intern Med ; Controlled level of dietary iodine normalizes serum total thyroxine in cats with naturally occurring hyperthyroidism abstract. Fritsch d, Allen T, Dodd C, et al. A restricted iodine food reduces circulating thyroxine concentrations in cats with hyperthyroidism. Changes in the glomerular filtration rate of 27 cats with hyperthyroidism after treatment with radioactive iodine. Vet Rec ; Syme HM. Cardiovascular and renal manifestations of hyperthyroidism.

Vet Clin Small Anim Pract ;— Appendix 1: Suggestions for questions for clients with cats with persistent hyperthyroidism. Leave a Reply Cancel reply Your email address will not be published. My family has had Lila since she was a kitten. She is turning 15 in October, I was only 10 when we got her.

I moved away as an adult for a few years Three months ago my 13 year old kitty Miss Fanny spent three days in the care of Dr. Vaughan and the staff. Before treatment she had been losing weight, getting more lethargic and her They are very personable, professional, and knowledgeable about their very specialized practice. If you have a cat with thyroid issues, I highly recommend this clinic.

Even better, he Thanks to Dr Faythe Vaughan, and her kind staff in Shoreline and Tacoma for giving us at least 5 extra, good quality, years with our buddy, Rocky! He was a rescue cat to begin with, and his good Princess started losing weight and after checking with the vet she was confirmed as being Hyperthyroid.

After Approximately 13 months of of a paste-like med applied to the ears, switching from left to right Monty is 12 years old. After discussing his overall appearance, behavior and appetite, we decided that Ripley kitty and I just wanted to thank Dr Vaughan and the whole staff for your great service and care. You were all great to work with, and communicated well with us!



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